Insertion technology for ASEP-TECH® Blow/Fill/Seal systems was pioneered by Weiler Engineering, Inc. The technology incorporates the use of a barrier isolator, typically located outside the machine room and integrated with the B/F/S machine. Sterile inserts such as tip and cap assemblies or multi-entry rubber stoppers are loaded into the isolator (which is maintained at Class 100 conditions) through a rapid transfer port.
The inserts are then indexed into the B/F/S machine where they are inserted into the molded container before the final top closure is formed. The entire operation takes place under Class 100 controlled environment conditions with no human intervention, providing a high level of sterility assurance for products that cannot be terminally sterilized.